Engineering the &#945;-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica.

Yovkova, Venelina; Otto, Christina; Aurich, Andreas; Mauersberger, Stephan; Barth, Gerold

Engineering the α-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica.

Yovkova, Venelina; Otto, Christina; Aurich, Andreas; Mauersberger, Stephan; Barth, Gerold.

Affiliation

Yovkova V; Institut für Mikrobiologie, Technische Universität Dresden, 01062, Dresden, Germany, veni772003@yahoo.de.

Appl Microbiol Biotechnol ; 98(5): 2003-13, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24276621

Subject(s)

Glycerol/metabolism; Isocitrate Dehydrogenase/metabolism; Ketoglutaric Acids/metabolism; Metabolic Engineering; Pyruvate Carboxylase/metabolism; Yarrowia/genetics; Yarrowia/metabolism; Bioreactors; Gene Dosage; Gene Expression; Isocitrate Dehydrogenase/genetics; Pyruvate Carboxylase/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Yarrowia/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Carboxylase / Yarrowia / Metabolic Engineering / Glycerol / Isocitrate Dehydrogenase / Ketoglutaric Acids Language: En Journal: Appl Microbiol Biotechnol Year: 2014 Document type: Article

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