Circadian disruption and cancer risk: a new concept of stromal niche (review).
Int J Oncol
; 44(2): 364-70, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-24297655
ABSTRACT
Circadian rhythms regulate a variety of physiological functions. Epidemiological evidence indicates that disruption of these circadian rhythms might be linked to cancer. In general, imbalances in homeostasis, such as immune and hormonal dysfunctions, are thought to be involved in cancer development. The results of a recent study suggested that circadian disruption may induce stromal changes associated with cancer risk, highlighting the importance of the cancer stem cell niche for protecting cancer cells. Current research provides new concepts and clarification regarding the function of the tumor niche, and the new concept of a stromal niche may help us to understand the additional functions of both cancer-associated fibroblasts and the extracellular matrix. In this review, we summarize our current knowledge regarding the role of circadian rhythms in cancer risk and the relevance of the stromal niche in cancer cell survival and progression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stromal Cells
/
Chronobiology Disorders
/
Stem Cell Niche
/
Neoplasms
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Oncol
Journal subject:
NEOPLASIAS
Year:
2014
Document type:
Article
Affiliation country:
Japan