Specificity of a UDP-GalNAc pyranose-furanose mutase: a potential therapeutic target for Campylobacter jejuni infections.

Poulin, Myles B; Shi, Yun; Protsko, Carla; Dalrymple, Sean A; Sanders, David A R; Pinto, B Mario; Lowary, Todd L

Poulin, Myles B; Shi, Yun; Protsko, Carla; Dalrymple, Sean A; Sanders, David A R; Pinto, B Mario; Lowary, Todd L.

Affiliation

Poulin MB; Alberta Glycomics Centre and Department of Chemistry, The University of Alberta, Gunning-Lemieux Chemistry Centre, 11227 Saskatchewan Drive, Edmonton, AB T6G 2G2 (Canada).

Chembiochem ; 15(1): 47-56, 2014 Jan 03.

Article in En | MEDLINE | ID: mdl-24302429

Subject(s)

Bacterial Proteins/metabolism; Campylobacter Infections/therapy; Campylobacter jejuni/enzymology; Intramolecular Transferases/metabolism; Arginine/metabolism; Bacterial Proteins/chemistry; Binding Sites; Biocatalysis; Campylobacter Infections/metabolism; Campylobacter Infections/pathology; Crystallography, X-Ray; Escherichia coli/enzymology; Humans; Intramolecular Transferases/chemistry; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Tertiary; Substrate Specificity; Uridine Diphosphate Galactose/chemistry; Uridine Diphosphate Galactose/metabolism; Uridine Diphosphate N-Acetylgalactosamine/chemistry; Uridine Diphosphate N-Acetylgalactosamine/metabolism

Key words

CORCEMA-ST calculations; NMR spectroscopy; X-ray crystallography; carbohydrates; molecular dynamics; pyranose-furanose mutase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Campylobacter Infections / Campylobacter jejuni / Intramolecular Transferases Limits: Humans Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2014 Document type: Article

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