Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers.
Colloids Surf B Biointerfaces
; 115: 15-21, 2014 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-24316584
ABSTRACT
In this study, we select naproxen (NAP) as a reference drug and electrospun poly (É-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (ßCD) to form inclusion complex (NAP-ßCD-IC) and then NAP-ßCD-IC was incorporated into PCL nanofibers via electrospinning. The incorporation of NAP without CD-IC into electrospun PCL was also carried out for a comparative study. Our aim is to analyze the release profiles of NAP from PCL/NAP and PCL/NAP-ßCD-IC nanofibers and we investigate the effect of CD-IC on the release behavior of NAP from the nanofibrous PCL matrix. The characterization of NAP-ßCD-IC and the presence of CD-IC in PCL/NAP-ßCD-IC nanofibers were studied by FTIR, XRD, TGA, NMR and SEM. The SEM imaging of the electrospun PCL/NAP and PCL/NAP-ßCD-IC nanofibers reveal that the average fiber diameter of these nanofibers is around 300nm, in addition, the aggregates of CD-IC in PCL/NAP-ßCD-IC nanofibers is observed. The release study of NAP in buffer solution elucidate that the PCL/NAP-ßCD-IC nanofibers have higher release amount of NAP than the PCL/NAP nanofibers due to the solubility enhancement of NAP by CD-IC.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyesters
/
Naproxen
/
Drug Delivery Systems
/
Tissue Engineering
/
Beta-Cyclodextrins
/
Nanofibers
Language:
En
Journal:
Colloids Surf B Biointerfaces
Journal subject:
QUIMICA
Year:
2014
Document type:
Article