MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

Terunuma, Atsushi; Putluri, Nagireddy; Mishra, Prachi; Mathé, Ewy A; Dorsey, Tiffany H; Yi, Ming; Wallace, Tiffany A; Issaq, Haleem J; Zhou, Ming; Killian, J Keith; Stevenson, Holly S; Karoly, Edward D; Chan, King; Samanta, Susmita; Prieto, DaRue; Hsu, Tiffany Y T; Kurley, Sarah J; Putluri, Vasanta; Sonavane, Rajni; Edelman, Daniel C; Wulff, Jacob; Starks, Adrienne M; Yang, Yinmeng; Kittles, Rick A; Yfantis, Harry G; Lee, Dong H; Ioffe, Olga B; Schiff, Rachel; Stephens, Robert M; Meltzer, Paul S; Veenstra, Timothy D; Westbrook, Thomas F; Sreekumar, Arun; Ambs, Stefan

Terunuma, Atsushi; Putluri, Nagireddy; Mishra, Prachi; Mathé, Ewy A; Dorsey, Tiffany H; Yi, Ming; Wallace, Tiffany A; Issaq, Haleem J; Zhou, Ming; Killian, J Keith; Stevenson, Holly S; Karoly, Edward D; Chan, King; Samanta, Susmita; Prieto, DaRue; Hsu, Tiffany Y T; Kurley, Sarah J; Putluri, Vasanta; Sonavane, Rajni; Edelman, Daniel C; Wulff, Jacob; Starks, Adrienne M; Yang, Yinmeng; Kittles, Rick A; Yfantis, Harry G; Lee, Dong H; Ioffe, Olga B; Schiff, Rachel; Stephens, Robert M; Meltzer, Paul S; Veenstra, Timothy D; Westbrook, Thomas F; Sreekumar, Arun; Ambs, Stefan.

J Clin Invest ; 124(1): 398-412, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24316975

Subject(s)

Breast Neoplasms/metabolism; Glutarates/metabolism; Proto-Oncogene Proteins c-myc/physiology; Alcohol Oxidoreductases/genetics; Alcohol Oxidoreductases/metabolism; Apoptosis; Breast Neoplasms/genetics; Breast Neoplasms/mortality; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutamine/metabolism; Humans; Isocitrate Dehydrogenase/genetics; Isocitrate Dehydrogenase/metabolism; MCF-7 Cells; Metabolome; Mitochondria/enzymology; Mitochondrial Proteins/genetics; Mitochondrial Proteins/metabolism; Prognosis; RNA, Small Interfering/genetics; Receptors, Estrogen/metabolism; Survival Analysis; Transcriptome; Wnt Signaling Pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Proto-Oncogene Proteins c-myc / Glutarates Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans Language: En Journal: J Clin Invest Year: 2014 Document type: Article Country of publication: United States

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