Neuronal inhibition by the peptide FMRFamide involves opening of S K+ channels.
Nature
; 325(7000): 153-6, 1987.
Article
in En
| MEDLINE
| ID: mdl-2433600
ABSTRACT
Neurotransmitters modulate the activity of ion channels through a variety of second messengers, including cyclic AMP, cyclic GMP and the products of phosphatidylinositol breakdown. Little is known about how different transmitters acting through different second-messenger systems interact within a cell to regulate single ion channels. We here describe the reciprocal actions of serotonin and the molluscan neuropeptide, FMRFamide, on individual K+ channels in Aplysia sensory neurons. In these cells, serotonin causes prolonged all-or-none closure of a class of background conductance K+ channels (the S channels) through cAMP-dependent protein phosphorylation. Using single-channel recording, we have found that FMRFamide produces two actions on the S channels; it increases the probability of opening of the S channels via a cAMP-independent second-messenger system and it reverses the closures of S channels produced by serotonin or cAMP.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aplysia
/
Potassium
/
Serotonin
/
Ion Channels
/
Nerve Tissue Proteins
/
Neural Inhibition
Limits:
Animals
Language:
En
Journal:
Nature
Year:
1987
Document type:
Article