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Effects of CYP2C19 and P450 oxidoreductase polymorphisms on the population pharmacokinetics of clobazam and N-desmethylclobazam in japanese patients with epilepsy.
Saruwatari, Junji; Ogusu, Naoki; Shimomasuda, Masatsugu; Nakashima, Hiroo; Seo, Takayuki; Tanikawa, Koji; Tsuda, Yoshiyuki; Nishimura, Miki; Nagata, Rie; Yasui-Furukori, Norio; Kaneko, Sunao; Ishitsu, Takateru; Nakagawa, Kazuko.
Affiliation
  • Saruwatari J; *Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan; †Department of Hospital Pharmacy, Yanagisawa Hospital, Ueda, Japan; ‡Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan; §Department of Pediatrics, Kumamoto Saishunso National Hospital, Kumamoto, Japan; and ¶Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
Ther Drug Monit ; 36(3): 302-9, 2014 Jun.
Article in En | MEDLINE | ID: mdl-24345815
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / NADPH-Ferrihemoprotein Reductase / Epilepsy / Cytochrome P-450 CYP2C19 / Anticonvulsants Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Ther Drug Monit Year: 2014 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / NADPH-Ferrihemoprotein Reductase / Epilepsy / Cytochrome P-450 CYP2C19 / Anticonvulsants Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Ther Drug Monit Year: 2014 Document type: Article Affiliation country: Japan