4E-BP1 regulates the sensitivity of human glioma cells to chemotherapy through PI3K/Akt/mTOR-independent pathway.

Zhu, Hui-Li; Xie, Si-Ming; Fang, Mao; Zhang, Ji-Jun; Weng, Ze-Ping; Zhong, Xue-Yun

Zhu, Hui-Li; Xie, Si-Ming; Fang, Mao; Zhang, Ji-Jun; Weng, Ze-Ping; Zhong, Xue-Yun.

Affiliation

Zhu HL; The First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Pathology, Medical College of Jinan University, Guangzhou, China.

Neuropathology ; 34(3): 227-35, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24354477

Subject(s)

Adaptor Proteins, Signal Transducing/physiology; Antineoplastic Agents, Alkylating/therapeutic use; Glioma/metabolism; Phosphatidylinositol 3-Kinase/biosynthesis; Phosphoproteins/physiology; Proto-Oncogene Proteins c-akt/biosynthesis; TOR Serine-Threonine Kinases/biosynthesis; Adaptor Proteins, Signal Transducing/biosynthesis; Antineoplastic Agents, Alkylating/pharmacology; Carmustine/pharmacology; Carmustine/therapeutic use; Cell Cycle Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/physiology; Glioma/drug therapy; Humans; Phosphoproteins/biosynthesis

Key words

4E-BP1; BCNU; chemotherapy; drug resistance; glioma

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Antineoplastic Agents, Alkylating / Adaptor Proteins, Signal Transducing / Proto-Oncogene Proteins c-akt / Phosphatidylinositol 3-Kinase / TOR Serine-Threonine Kinases / Glioma Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Neuropathology Journal subject: NEUROLOGIA / PATOLOGIA Year: 2014 Document type: Article Affiliation country: China

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