A sensitive LC-MS/MS method for simultaneous determination of R-bambuterol and its active metabolite R-terbutaline in human plasma and urine with application to a clinical pharmacokinetic study.

Zhou, Ting; Zhao, Ting; Cheng, Qing; Liu, Shan; Xu, Ling; Tan, Wen

Zhou, Ting; Zhao, Ting; Cheng, Qing; Liu, Shan; Xu, Ling; Tan, Wen.

Affiliation

Zhou T; School of Bioscience and Bioengineer, South China University of Technology, Guangzhou, Guangdong, 510006, China.

Biomed Chromatogr ; 28(7): 994-1002, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24357101

Subject(s)

Chromatography, Liquid/methods; Tandem Mass Spectrometry/methods; Terbutaline/analogs & derivatives; Terbutaline/blood; Terbutaline/urine; Administration, Oral; Biotransformation; Drug Stability; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Terbutaline/administration & dosage; Terbutaline/pharmacokinetics

Key words

LC-MS/MS; R-bambuterol; R-terbutaline; pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Terbutaline / Chromatography, Liquid / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Biomed Chromatogr Year: 2014 Document type: Article Affiliation country: China Country of publication: United kingdom

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