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Oleanolic acid acetate inhibits osteoclast differentiation by downregulating PLCγ2-Ca(2+)-NFATc1 signaling, and suppresses bone loss in mice.
Kim, Ju-Young; Cheon, Yoon-Hee; Oh, Hyun Mee; Rho, Mun Chual; Erkhembaatar, Munkhsoyol; Kim, Min Seuk; Lee, Chang Hoon; Kim, Jeong Joong; Choi, Min Kyu; Yoon, Kwon-Ha; Lee, Myeung Su; Oh, Jaemin.
Affiliation
  • Kim JY; Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Cheon YH; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Oh HM; Bioindustrial Process Research Center, Bio-Materials Research Institute, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 580-185, Republic of Korea.
  • Rho MC; Bioindustrial Process Research Center, Bio-Materials Research Institute, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 580-185, Republic of Korea.
  • Erkhembaatar M; Department of Oral Physiology, School of Dentistry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Kim MS; Department of Oral Physiology, School of Dentistry, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Lee CH; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Kim JJ; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Choi MK; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Yoon KH; Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Department of Radiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea.
  • Lee MS; Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Division of Rheumatology, Department of Internal Medicine, Wonkwang University
  • Oh J; Imaging Science-based Lung and Bone Diseases Research Center, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Department of Anatomy, School of Medicine, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea; Institute for Skeletal Disease, Wonkwang University, Iksan, Jeonbuk
Bone ; 60: 104-11, 2014 Mar.
Article in En | MEDLINE | ID: mdl-24361669
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Bone Resorption / Down-Regulation / Cell Differentiation / Calcium / Phospholipase C gamma / NFATC Transcription Factors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Bone Journal subject: METABOLISMO / ORTOPEDIA Year: 2014 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Bone Resorption / Down-Regulation / Cell Differentiation / Calcium / Phospholipase C gamma / NFATC Transcription Factors Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Bone Journal subject: METABOLISMO / ORTOPEDIA Year: 2014 Document type: Article Country of publication: United States