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DW09849, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110α (H1047R).
Liu, Jia-li; Gao, Guo-rui; Zhang, Xi; Cao, Su-fen; Guo, Chen-liang; Wang, Xiang; Tong, Lin-jiang; Ding, Jian; Duan, Wen-hu; Meng, Ling-hua.
Affiliation
  • Liu JL; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research (J.-l.L., X.Z., C.-l.G., X.W., L-j.T., J.D., L-h.M.) and Department of Medicinal Chemistry (W-h.D.), Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China; and School of Pharmacy, East China University of Science and Technology, Shanghai, P.R. China (G.-r.G., S.-f.C. W.-h.D.).
J Pharmacol Exp Ther ; 348(3): 432-41, 2014 Mar.
Article in En | MEDLINE | ID: mdl-24361696
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogenes / Cell Proliferation / Class Ia Phosphatidylinositol 3-Kinase / Phosphoinositide-3 Kinase Inhibitors / Heterocyclic Compounds, 2-Ring / Hydrazones / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2014 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogenes / Cell Proliferation / Class Ia Phosphatidylinositol 3-Kinase / Phosphoinositide-3 Kinase Inhibitors / Heterocyclic Compounds, 2-Ring / Hydrazones / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Pharmacol Exp Ther Year: 2014 Document type: Article Country of publication: United States