Probing the orthosteric binding site of GABAA receptors with heterocyclic GABA carboxylic acid bioisosteres.

Petersen, Jette G; Bergmann, Rikke; Krogsgaard-Larsen, Povl; Balle, Thomas; Frølund, Bente

Petersen, Jette G; Bergmann, Rikke; Krogsgaard-Larsen, Povl; Balle, Thomas; Frølund, Bente.

Affiliation

Petersen JG; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100, Copenhagen, Denmark.

Neurochem Res ; 39(6): 1005-15, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24362592

Subject(s)

Carboxylic Acids/metabolism; Heterocyclic Compounds/metabolism; Receptors, GABA-A/metabolism; gamma-Aminobutyric Acid/metabolism; Animals; Binding Sites/physiology; Carboxylic Acids/chemistry; Heterocyclic Compounds/chemistry; Humans; Protein Binding/physiology; Structure-Activity Relationship; gamma-Aminobutyric Acid/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carboxylic Acids / Receptors, GABA-A / Gamma-Aminobutyric Acid / Heterocyclic Compounds Limits: Animals / Humans Language: En Journal: Neurochem Res Year: 2014 Document type: Article Affiliation country: Denmark Country of publication: United States

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