5-Aza-2<-deoxycytidine induces hepatoma cell apoptosis via enhancing methionine adenosyltransferase 1A expression and inducing S-adenosylmethionine production.

Liu, Wei-Jun; Ren, Jian-Guo; Li, Ting; Yu, Guo-Zheng; Zhang, Jin; Li, Chang-Sheng; Liu, Zhi-Su; Liu, Quan-Yan

Liu, Wei-Jun; Ren, Jian-Guo; Li, Ting; Yu, Guo-Zheng; Zhang, Jin; Li, Chang-Sheng; Liu, Zhi-Su; Liu, Quan-Yan.

Affiliation

Liu WJ; Department of General Surgery, Research Center of Digestive Diseases, Zhongnan Hospital, Wuhan University, Wuhan, China E-mail : lqy@whu. edu.cn, spss2005@126.com.

Asian Pac J Cancer Prev ; 14(11): 6433-8, 2013.

Article in En | MEDLINE | ID: mdl-24377546

Subject(s)

Apoptosis/drug effects; Azacitidine/analogs & derivatives; Carcinoma, Hepatocellular/drug therapy; Liver Neoplasms/drug therapy; Methionine Adenosyltransferase/biosynthesis; S-Adenosylmethionine/biosynthesis; Azacitidine/pharmacology; Carcinoma, Hepatocellular/genetics; Carcinoma, Hepatocellular/metabolism; Carcinoma, Hepatocellular/pathology; Caspase 3/genetics; Cell Line, Tumor; DNA Methylation/drug effects; Decitabine; Down-Regulation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Liver Neoplasms/genetics; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; Methionine Adenosyltransferase/genetics; Proto-Oncogene Proteins c-bcl-2/genetics; S-Adenosylmethionine/genetics; Up-Regulation/drug effects; bcl-2-Associated X Protein/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: S-Adenosylmethionine / Azacitidine / Apoptosis / Carcinoma, Hepatocellular / Liver Neoplasms / Methionine Adenosyltransferase Limits: Humans Language: En Journal: Asian Pac J Cancer Prev Journal subject: NEOPLASIAS Year: 2013 Document type: Article

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