Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.

Eckle, Tobias; Kewley, Emily M; Brodsky, Kelley S; Tak, Eunyoung; Bonney, Stephanie; Gobel, Merit; Anderson, Devon; Glover, Louise E; Riegel, Ann K; Colgan, Sean P; Eltzschig, Holger K

Eckle, Tobias; Kewley, Emily M; Brodsky, Kelley S; Tak, Eunyoung; Bonney, Stephanie; Gobel, Merit; Anderson, Devon; Glover, Louise E; Riegel, Ann K; Colgan, Sean P; Eltzschig, Holger K.

Affiliation

Eckle T; Mucosal Inflammation Program, Department of Anesthesiology, University of Colorado, Aurora, CO 80045.

J Immunol ; 192(3): 1249-56, 2014 Feb 01.

Article in En | MEDLINE | ID: mdl-24391213

Subject(s)

Acute Lung Injury/physiopathology; Hypoxia-Inducible Factor 1, alpha Subunit/physiology; Receptor, Adenosine A2B/genetics; Stress, Mechanical; Ventilator-Induced Lung Injury/physiopathology; Acute Lung Injury/metabolism; Adenosine/physiology; Animals; Binding Sites; Cells, Cultured; Epithelial Cells/physiology; Female; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/deficiency; Lung/metabolism; Lung/physiopathology; Male; Mice; Mice, Knockout; Mice, Transgenic; Promoter Regions, Genetic/genetics; Receptor, Adenosine A2B/biosynthesis; Receptor, Adenosine A2B/physiology; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Mechanical / Receptor, Adenosine A2B / Hypoxia-Inducible Factor 1, alpha Subunit / Acute Lung Injury / Ventilator-Induced Lung Injury Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunol Year: 2014 Document type: Article Country of publication: United States

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