Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses.

Gad, Nicholas A; Mizdrak, Jasminka; Pattison, David I; Davies, Michael J; Truscott, Roger J W; Jamie, Joanne F

Gad, Nicholas A; Mizdrak, Jasminka; Pattison, David I; Davies, Michael J; Truscott, Roger J W; Jamie, Joanne F.

Affiliation

Gad NA; Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, Australia.

Invest Ophthalmol Vis Sci ; 55(2): 849-55, 2014 Feb 10.

Article in En | MEDLINE | ID: mdl-24408982

Subject(s)

Glucosides/analysis; Lens, Crystalline/chemistry; Adolescent; Adult; Aged; Aged, 80 and over; Cataract/metabolism; Chromatography, High Pressure Liquid; Glucosides/chemical synthesis; Glucosides/chemistry; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Phenylbutyrates/analysis; Phenylbutyrates/chemical synthesis; Phenylbutyrates/chemistry; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Young Adult

Key words

UV filters; age related nuclear cataract; photooxidation; tryptophan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glucosides / Lens, Crystalline Type of study: Diagnostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Language: En Journal: Invest Ophthalmol Vis Sci Year: 2014 Document type: Article Affiliation country: Australia Country of publication: United States

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