γ-Secretase modulators: current status and future directions.
Prog Med Chem
; 53: 101-45, 2014.
Article
in En
| MEDLINE
| ID: mdl-24418609
ABSTRACT
This chapter reviews the current status of γ-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes acids, imidazoles and related derivatives and natural products. A section on chemical biology and ligand-binding site elucidation studies is also included. The primary source of information is drawn from peer reviewed literature as this permits analysis of PK-PD relationships and subsequent comment. Discussion of the patent literature is included for completeness. From this analysis, the key issues and challenges in the area are highlighted. The review concludes with a summary of the clinical development status and comment on future prospects of the field.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amyloid Precursor Protein Secretases
/
Alzheimer Disease
Limits:
Animals
/
Humans
Language:
En
Journal:
Prog Med Chem
Year:
2014
Document type:
Article
Affiliation country:
United kingdom