Hepatic ALECT-2 amyloidosis causing portal hypertension and recurrent variceal bleeding: a case report and review of the literature.
Am J Clin Pathol
; 141(2): 288-91, 2014 Feb.
Article
in En
| MEDLINE
| ID: mdl-24436280
ABSTRACT
OBJECTIVES:
To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins.RESULTS:
ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS.METHODS:
One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chemotaxin 2) amyloid, found in renal specimens of Hispanic patients. Here we report the first case of hepatic ALECT-2 amyloidosis diagnosed by LMD-MS from a liver biopsy specimen of a 52-year-old Hispanic man and causing portal hypertension with recurrent esophageal variceal bleeding.CONCLUSIONS:
ALECT-2 can cause amyloidosis in organs other than the kidneys. It should be strongly considered in Hispanic patients and in those with a globular pattern of amyloid deposition. The incidence of ALECT-2 amyloidosis is likely underreported.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Intercellular Signaling Peptides and Proteins
/
Gastrointestinal Hemorrhage
/
Amyloidosis
/
Hypertension, Portal
/
Liver Diseases
Type of study:
Etiology_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Clin Pathol
Year:
2014
Document type:
Article