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DNA directed immobilization glycocluster array: applications and perspectives.
Chevolot, Yann; Laurenceau, Emmanuelle; Phaner-Goutorbe, Magali; Monnier, Virginie; Souteyrand, Eliane; Meyer, Albert; Géhin, Thomas; Vasseur, Jean-Jacques; Morvan, François.
Affiliation
  • Chevolot Y; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France. Electronic address: yann.chevolot@ec-lyon.fr.
  • Laurenceau E; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France.
  • Phaner-Goutorbe M; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France.
  • Monnier V; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France.
  • Souteyrand E; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France.
  • Meyer A; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - Université Montpellier 1 - Université Montpellier 2, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France.
  • Géhin T; Université de Lyon, Institut des Nanotechnologies de Lyon UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully Cedex, France.
  • Vasseur JJ; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - Université Montpellier 1 - Université Montpellier 2, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France.
  • Morvan F; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS - Université Montpellier 1 - Université Montpellier 2, Place Eugène Bataillon, CC1704, 34095 Montpellier Cedex 5, France. Electronic address: morvan@univ-montp2.fr.
Curr Opin Chem Biol ; 18: 46-54, 2014 Feb.
Article in En | MEDLINE | ID: mdl-24440778
The present review concerns the recent advances in DNA directed immobilization (DDI) based glycocluster array. The impact of glycan immobilization on subsequent interactions with protein is discussed and the consequent pros and cons of DDI-based glycocluster array are reviewed. Finally, application in the discovery of anti-pathogen molecules is illustrated by screening for galactose or fucose glycoclusters targeting two Pseudomonas aeruginosa virulence factors (PA-IL and PA-IIL).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Glycomics / Fucose / Galactose Language: En Journal: Curr Opin Chem Biol Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA / Glycomics / Fucose / Galactose Language: En Journal: Curr Opin Chem Biol Journal subject: BIOQUIMICA Year: 2014 Document type: Article Country of publication: United kingdom