p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan, Senthil K; den Besten, Willem; Deshaies, Raymond J

Radhakrishnan, Senthil K; den Besten, Willem; Deshaies, Raymond J.

Affiliation

Radhakrishnan SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.

Elife ; 3: e01856, 2014.

Article in En | MEDLINE | ID: mdl-24448410

Subject(s)

Adenosine Triphosphatases/metabolism; Cell Cycle Proteins/metabolism; Endoplasmic Reticulum/metabolism; Nuclear Respiratory Factor 1/metabolism; Proteasome Endopeptidase Complex/drug effects; Proteasome Inhibitors/pharmacology; Adenosine Triphosphatases/genetics; Animals; Cell Cycle Proteins/genetics; HEK293 Cells; Humans; Mice; Mutation; NIH 3T3 Cells; Nuclear Respiratory Factor 1/genetics; Proteasome Endopeptidase Complex/genetics; Proteasome Endopeptidase Complex/metabolism; Protein Processing, Post-Translational; Protein Transport; Proteolysis; RNA Interference; Transcription, Genetic; Transcriptional Activation; Transfection; Valosin Containing Protein

Key words

Nrf1; p97; proteasome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adenosine Triphosphatases / Cell Cycle Proteins / Proteasome Endopeptidase Complex / Endoplasmic Reticulum / Nuclear Respiratory Factor 1 / Proteasome Inhibitors Limits: Animals / Humans Language: En Journal: Elife Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

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