Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and ¹H-NMR-based extracellular metabonomic assays.

Irfan, Adeel; Cauchi, Michael; Edmands, William; Gooderham, Nigel J; Njuguna, James; Zhu, Huijun

Irfan, Adeel; Cauchi, Michael; Edmands, William; Gooderham, Nigel J; Njuguna, James; Zhu, Huijun.

Affiliation

Irfan A; School of Applied Sciences, Cranfield University, Bedfordshire, MK43 0AL, UK.

Toxicol Sci ; 138(2): 354-64, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24449423

Subject(s)

Air Pollutants/toxicity; Extracellular Fluid/metabolism; Lung/drug effects; Metabolome/drug effects; Nanoparticles/chemistry; Silicon Dioxide/toxicity; Air Pollutants/chemistry; Cell Culture Techniques; Cell Line; Cell Survival/drug effects; Culture Media; Dose-Response Relationship, Drug; Humans; Lung/metabolism; Lung/pathology; Magnetic Resonance Spectroscopy; Microscopy, Electron, Transmission; Multivariate Analysis; Particle Size; Reactive Oxygen Species/metabolism; Scattering, Radiation; Silicon Dioxide/chemistry; Surface Properties

Key words

1H-NMR metabonomics; A549 cells; Fumed silica nanoparticles; cytotoxicity; dose-effect relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silicon Dioxide / Extracellular Fluid / Air Pollutants / Nanoparticles / Metabolome / Lung Limits: Humans Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States

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