[Recombinant thrombopoietin antiradiation therapeutic effectiveness evaluation on dogs according to hemopoiesis and survival criteria].
Radiats Biol Radioecol
; 53(3): 280-9, 2013.
Article
in Ru
| MEDLINE
| ID: mdl-24450209
ABSTRACT
Recombinant human thrombopoietin (rh TPO) has been investigated as a means of acute radiation disease urgent treatment in the experiments on 24 mongrel dogs. The animals were exposed to total acute gamma-irradiation at the doses of 3.5 Gy (exceeding LD50/45 under our conditions) and 3 Gy. All the dogs including control ones received antibiotics Ampicillin and Gentamicin twice a day during the acute period from the 7th to the 21st day. TPO was injected one time s/c or i/v at the doses of5 or 10 mkg/kg 1.5-2 h after exposure. TPO at a dose of 5 mkg/kg was ineffective. TPO at a dose of 10 mkg/kg had a positive effect on the kinetics of blood forming units, especially platelets (nadir, restoration rate) in terms of the 45-day survival. As a result, in TPO groups, nadir averaged at both exposure doses on leucocytes (1.3-1.4) x 10(9)/l vs (0.70-0.75) x 10(9)/l in control groups and on thrombocytes (102-112) x 10(9)/l vs (44-33) x 10(9)/l in control ones. Despite the low number of animals in experimental groups, the results permit to regard rhTPO as a worth-while urgent therapeutic means for the acute radiation damage treatment and preventing thrombopenia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thrombopoietin
/
Recombinant Proteins
/
Acute Radiation Syndrome
/
Hematopoiesis
Limits:
Animals
/
Humans
Language:
Ru
Journal:
Radiats Biol Radioecol
Journal subject:
GENETICA
/
MEDICINA NUCLEAR
Year:
2013
Document type:
Article