Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A.

Kawamura, Shuhei; Unno, Yuka; Hirokawa, Takatsugu; Asai, Akira; Arisawa, Mitsuhiro; Shuto, Satoshi

Kawamura, Shuhei; Unno, Yuka; Hirokawa, Takatsugu; Asai, Akira; Arisawa, Mitsuhiro; Shuto, Satoshi.

Affiliation

Kawamura S; Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. shu@pharm.hokudai.ac.jp.

Chem Commun (Camb) ; 50(19): 2445-7, 2014 Mar 07.

Article in En | MEDLINE | ID: mdl-24452398

Subject(s)

Biological Products/chemistry; Peptides/chemistry; Proteasome Inhibitors/chemistry; Cell Survival/drug effects; HCT116 Cells; Humans; Intercellular Signaling Peptides and Proteins; Proteasome Inhibitors/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Biological Products / Proteasome Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2014 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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