The extraction of antiepileptic drugs. Model study on partition coefficients.
Arzneimittelforschung
; 28(1): 19-21, 1978.
Article
in En
| MEDLINE
| ID: mdl-24454
ABSTRACT
To compare the extraction behaviour of hexane, toluene, chloroform, 1,2-dichloroethane, diethylether, ethyl acetate and acetone towards phenobarbital, phenytoin, primidone and carbamazepine, partition coefficients of these drugs between the above solvents and water (saturated with ammonium sulphate when working with acetone) were measured at different pH-conditions. Acetone rendered the highest partition coefficients for all drugs. Ethyl acetate was second in the range, except for carbamazepine, which showed a specific affinity for the chlorinated hydrocarbons.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anticonvulsants
Language:
En
Journal:
Arzneimittelforschung
Year:
1978
Document type:
Article