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Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.
Ko, Myoung Seok; Kim, Hyo Jeong; Kim, Hong Kyung; Yoon, Nal Ae; Lee, Unn Hwa; Lee, Sang Chul; Chung, Dae Kyun; Lee, Byung Ju; Suh, Jae Hee; Cho, Wha Ja; Park, Jeong Woo.
Affiliation
  • Ko MS; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea; Department of Medical Science, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
  • Kim HJ; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
  • Kim HK; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
  • Yoon NA; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
  • Lee UH; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
  • Lee SC; Personalized Medicine System R&D Center, Bio-Support Co., Ltd., Anyang, Kyeonggi-Do 431-810, South Korea.
  • Chung DK; School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 449-701, South Korea.
  • Lee BJ; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
  • Suh JH; Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.
  • Cho WJ; Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.
  • Park JW; Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea. Electronic address: jwpark@ulsan.ac.kr.
Clin Immunol ; 150(2): 225-35, 2014 Feb.
Article in En | MEDLINE | ID: mdl-24463315
ABSTRACT
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of T(H)17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: GTP-Binding Proteins / Encephalomyelitis, Autoimmune, Experimental / Th17 Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: South Korea
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: GTP-Binding Proteins / Encephalomyelitis, Autoimmune, Experimental / Th17 Cells Type of study: Prognostic_studies Limits: Animals Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Document type: Article Affiliation country: South Korea