Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.

Rowe, Isaline; Chiaravalli, Marco; Piontek, Klaus B; Germino, Gregory G; Boletta, Alessandra

Rowe, Isaline; Chiaravalli, Marco; Piontek, Klaus B; Germino, Gregory G; Boletta, Alessandra.

Affiliation

Rowe I; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Chiaravalli M; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Piontek KB; Johns Hopkins University School of Medicine, Division of Nephrology, Baltimore, MD, USA.
Germino GG; Johns Hopkins University School of Medicine, Division of Nephrology, Baltimore, MD, USA.
Boletta A; Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy. Electronic address: boletta.alessandra@hsr.it.

Biochem Biophys Res Commun ; 444(4): 473-9, 2014 Feb 21.

Article in En | MEDLINE | ID: mdl-24472557

Subject(s)

Kidney Glomerulus/embryology; Kidney Glomerulus/physiopathology; Polycystic Kidney, Autosomal Dominant/genetics; Polycystic Kidney, Autosomal Dominant/physiopathology; TRPP Cation Channels/genetics; Animals; Cell Movement; Endothelial Cells/cytology; Endothelial Cells/metabolism; Endothelial Cells/pathology; Gene Deletion; Kidney Glomerulus/metabolism; Mice; Mutation; Organ Culture Techniques; Phosphoinositide-3 Kinase Inhibitors; TRPP Cation Channels/metabolism

Key words

Endothelial cell migration; Glomerulogenesis; Kidney development; Polycystic kidney disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycystic Kidney, Autosomal Dominant / TRPP Cation Channels / Kidney Glomerulus Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2014 Document type: Article Affiliation country: Italy Country of publication: United States

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