Foamy macrophage responses in the rat lung following exposure to inhaled pharmaceuticals: a simple, pragmatic approach for inhaled drug development.

Lewis, David J; Williams, Thomas C; Beck, Steven L

Lewis, David J; Williams, Thomas C; Beck, Steven L.

Affiliation

Lewis DJ; Safety Assessment, GlaxoSmithKline, Ware, Herts, SG12 0DP, UK.

J Appl Toxicol ; 34(4): 319-31, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24474237

Subject(s)

Adrenal Cortex Hormones/adverse effects; Adrenergic beta-2 Receptor Antagonists/adverse effects; Drug Discovery; Foam Cells/drug effects; Lung/drug effects; Macrophages, Alveolar/drug effects; Muscarinic Antagonists/adverse effects; Administration, Inhalation; Adrenal Cortex Hormones/administration & dosage; Adrenal Cortex Hormones/chemistry; Adrenergic beta-2 Receptor Antagonists/administration & dosage; Adrenergic beta-2 Receptor Antagonists/chemistry; Animals; Foam Cells/immunology; Foam Cells/ultrastructure; Lung/immunology; Lung/ultrastructure; Macrophages, Alveolar/immunology; Macrophages, Alveolar/ultrastructure; Muscarinic Antagonists/administration & dosage; Muscarinic Antagonists/chemistry; Neutrophil Infiltration/drug effects; Neutrophil Infiltration/immunology; Phagocytosis/drug effects; Phagocytosis/immunology; Rats; Solubility

Key words

Foamy; accumulation; adversity; aetiology; inhaled; macrophage; pharmaceuticals

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macrophages, Alveolar / Adrenal Cortex Hormones / Muscarinic Antagonists / Drug Discovery / Adrenergic beta-2 Receptor Antagonists / Foam Cells / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Appl Toxicol Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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