Association of CDKN2A polymorphisms with the severity of cervical neoplasia in a Brazilian population.
Biomarkers
; 19(2): 121-7, 2014 Mar.
Article
in En
| MEDLINE
| ID: mdl-24491138
ABSTRACT
Variants of p16(INK4a) and p14(ARF), encoded by the CDKN2A locus, may respond differently to the presence of human papillomavirus (HPV). We investigated the potential association of two CDKN2A polymorphisms, 500C > G (rs11515) and 540C > T (rs3088440), with cervical neoplasia in patients with cervical lesions and healthy controls (n = 492). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), single-strand conformation polymorphism (SSCP) and/or DNA sequencing techniques were employed for genotyping. The 500G allele was found higher, whereas the 540T/T genotype was less frequent in patients with more severe lesions. The CDKN2A variants may have the potential to be markers for the management of patients with cervical neoplasia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Cyclin-Dependent Kinase Inhibitor p16
/
Polymorphism, Single Nucleotide
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Biomarkers
Journal subject:
BIOQUIMICA
Year:
2014
Document type:
Article