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Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein.
Villar, Victor Hugo; Vögler, Oliver; Barceló, Francisca; Gómez-Florit, Manuel; Martínez-Serra, Jordi; Obrador-Hevia, Antònia; Martín-Broto, Javier; Ruiz-Gutiérrez, Valentina; Alemany, Regina.
Affiliation
  • Villar VH; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.
  • Vögler O; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.
  • Barceló F; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.
  • Gómez-Florit M; Group of Cell Therapy and Tissue Engineering, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain.
  • Martínez-Serra J; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain; Department of Hematology, University Hospital Son Espases, Palma de Mallorca, Spain.
  • Obrador-Hevia A; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain; Department of Oncology, University Hospital Son Espases, Palma de Mallorca, Spain.
  • Martín-Broto J; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain; Department of Oncology, University Hospital Son Espases, Palma de Mallorca, Spain.
  • Ruiz-Gutiérrez V; Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), Seville, Spain; CIBER:CB06/03 Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud, Carlos III (ISCIII), Spain.
  • Alemany R; Group of Clinical and Translational Research, Department of Biology, Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of the Balearic Islands, Palma de Mallorca, Spain; CIBER:CB06/03 Fisiopatología de la Obesidad y la Nutrición, CIBERobn, Instituto de Salud, Carlos
J Nutr Biochem ; 25(4): 429-38, 2014 Apr.
Article in En | MEDLINE | ID: mdl-24491315
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Sarcoma / Triterpenes / Doxorubicin / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Multidrug Resistance-Associated Proteins Limits: Humans Language: En Journal: J Nutr Biochem Journal subject: BIOQUIMICA / CIENCIAS DA NUTRICAO Year: 2014 Document type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Sarcoma / Triterpenes / Doxorubicin / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Multidrug Resistance-Associated Proteins Limits: Humans Language: En Journal: J Nutr Biochem Journal subject: BIOQUIMICA / CIENCIAS DA NUTRICAO Year: 2014 Document type: Article Affiliation country: Spain