Autochthonous Dobrava-Belgrade virus infection in Eastern Germany.
Clin Nephrol
; 83(2): 111-6, 2015 Feb.
Article
in En
| MEDLINE
| ID: mdl-24495905
ABSTRACT
A 21-year-old male patient from Borna, Saxony, in Eastern Germany, suffered from acute kidney injury (AKI) and symptoms typical for a hantavirus infection. These symptoms included nausea, vomiting, abdominal pain, diarrhea, and acute renal failure. Serological investigations by indirect IgM and IgG in-house ELISAs, commercial immunofluorescence and line assays, as well as chemiluminescence focus reduction neutralization assay confirmed an acute Dobrava-Belgrade virus (DOBV) infection of the patient. Serological and RT-PCR analyses of striped field mouse (Apodemus agrarius) trapped in a neighboring region of the residence of the patient identified an infection by DOBV, genotype Kurkino. This is the first report of an autochthonous DOBV infection in a German patient living far from the known endemic region in the north of the country. This finding has implications for the awareness of physicians in areas which are not recognized as hantavirus endemic regions but where the reservoir host of the virus is present.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthohantavirus
/
Hantavirus Infections
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Animals
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
En
Journal:
Clin Nephrol
Year:
2015
Document type:
Article