A review of methylene blue treatment for cardiovascular collapse.
J Emerg Med
; 46(5): 670-9, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24508113
ABSTRACT
BACKGROUND:
Historically, methylene blue (MB) has been used for multiple purposes, including as an antidote for toxin-induced and hereditary methemoglobinemia, ifosfamide-induced encephalopathy, and ackee fruit and cyanide poisoning; as an aniline dye derivative, antimalarial agent, and antidepressant.DISCUSSION:
Most recently, the use of MB has been advocated as a potential adjunct in the treatment of shock states. Our article reviews the role of MB in septic shock, anaphylactic shock, and toxin-induced shock. MB is proposed to increase blood pressure in these shock states by interfering with guanylate cyclase activity, and preventing cyclic guanosine monophosphate production and vasodilatation.SUMMARY:
MB may be an adjunct in the treatment of septic shock, anaphylactic shock, and toxin-induced shock.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Shock
/
Enzyme Inhibitors
/
Anaphylaxis
/
Methylene Blue
Limits:
Humans
Language:
En
Journal:
J Emerg Med
Journal subject:
MEDICINA DE EMERGENCIA
Year:
2014
Document type:
Article