Effect of food deprivation on formalin-induced nociceptive behaviors and ß-endorphin and sex hormone concentration in rats.
Iran Biomed J
; 18(2): 107-13, 2014.
Article
in En
| MEDLINE
| ID: mdl-24518552
ABSTRACT
BACKGROUND:
The present study examined the possible role of endogenous opioidergic system in effect of food deprivation on formalin-induced nociceptive behaviors in male and female rats. Also, we investigated the effect of food deprivation on the plasma level of beta-endorphin and sex hormones.METHODS:
Food was withdrawn 48 h prior to performing the formalin test, but water continued to be available ad libitum. The formalin was injected into hind plantar paw.RESULTS:
There is significant difference between male and female control rats during phase 2B. Following 48-h food deprivation, both male and female rats exhibited enhanced nociceptive behavior in response to formalin. Food deprivation for 12 and 24 h increased and for 48 h decreased beta-endorphin level in male and female rats. Food deprivation for 24 h decreased testosterone level in male, while it had no significant effect on female rats and food deprivation for 48 h decreased testosterone level in both sexes. Food deprivation for 24 h increased estradiol level in female and that for 48 h had no significant effect on male and female rats.CONCLUSIONS:
The present study demonstrates the existence of food deprivation for 48 h causes enhancement of nociception in the formalin test in male and female rats that has correlation with decrease in plasma beta-endorphin and testosterone levels.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gonadal Steroid Hormones
/
Beta-Endorphin
/
Sex Characteristics
/
Nociception
/
Food Deprivation
/
Formaldehyde
Limits:
Animals
Language:
En
Journal:
Iran Biomed J
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2014
Document type:
Article
Affiliation country:
Iran