Local hydrogel release of recombinant TIMP-3 attenuates adverse left ventricular remodeling after experimental myocardial infarction.

Eckhouse, Shaina R; Purcell, Brendan P; McGarvey, Jeremy R; Lobb, David; Logdon, Christina B; Doviak, Heather; O'Neill, Jason W; Shuman, James A; Novack, Craig P; Zellars, Kia N; Pettaway, Sara; Black, Roy A; Khakoo, Aarif; Lee, Taeweon; Mukherjee, Rupak; Gorman, Joseph H; Gorman, Robert C; Burdick, Jason A; Spinale, Francis G

Eckhouse, Shaina R; Purcell, Brendan P; McGarvey, Jeremy R; Lobb, David; Logdon, Christina B; Doviak, Heather; O'Neill, Jason W; Shuman, James A; Novack, Craig P; Zellars, Kia N; Pettaway, Sara; Black, Roy A; Khakoo, Aarif; Lee, Taeweon; Mukherjee, Rupak; Gorman, Joseph H; Gorman, Robert C; Burdick, Jason A; Spinale, Francis G.

Affiliation

Eckhouse SR; Cardiothoracic Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.

Sci Transl Med ; 6(223): 223ra21, 2014 Feb 12.

Article in En | MEDLINE | ID: mdl-24523321

Subject(s)

Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry; Myocardial Infarction/drug therapy; Myocardial Infarction/metabolism; Tissue Inhibitor of Metalloproteinase-3/administration & dosage; Tissue Inhibitor of Metalloproteinase-3/therapeutic use; Ventricular Remodeling/physiology; Animals; Disease Models, Animal; Hydrogel, Polyethylene Glycol Dimethacrylate/administration & dosage; Tissue Inhibitor of Metalloproteinase-3/metabolism; Ventricular Remodeling/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tissue Inhibitor of Metalloproteinase-3 / Hydrogel, Polyethylene Glycol Dimethacrylate / Ventricular Remodeling / Myocardial Infarction Limits: Animals Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Document type: Article Affiliation country: United States Country of publication: United States

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