Short communication: SAHA (vorinostat) induces CDK9 Thr-186 (T-loop) phosphorylation in resting CD4+ T cells: implications for reactivation of latent HIV.

Ramakrishnan, Rajesh; Liu, Hongbing; Rice, Andrew P

Ramakrishnan, Rajesh; Liu, Hongbing; Rice, Andrew P.

Affiliation

Ramakrishnan R; Department of Molecular Virology and Microbiology, Baylor College of Medicine , Houston, Texas.

AIDS Res Hum Retroviruses ; 31(1): 137-41, 2015 Jan.

Article in En | MEDLINE | ID: mdl-24528253

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Cyclin-Dependent Kinase 9/metabolism; Disulfiram/pharmacology; Hydroxamic Acids/pharmacology; Positive Transcriptional Elongation Factor B/metabolism; Acetaldehyde Dehydrogenase Inhibitors/pharmacology; Cell Line; Cyclin T/biosynthesis; HIV Infections/virology; HIV-1/physiology; Histone Deacetylase Inhibitors/pharmacology; Humans; Jurkat Cells; Phosphorylation/drug effects; Virus Activation/drug effects; Virus Latency; Vorinostat

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Cyclin-Dependent Kinase 9 / Positive Transcriptional Elongation Factor B / Disulfiram / Hydroxamic Acids Limits: Humans Language: En Journal: AIDS Res Hum Retroviruses Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2015 Document type: Article

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