Wnt/ß-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma.

Pöschl, Julia; Bartels, Martin; Ohli, Jasmin; Bianchi, Edoardo; Kuteykin-Teplyakov, Konstantin; Grammel, Daniel; Ahlfeld, Julia; Schüller, Ulrich

Pöschl, Julia; Bartels, Martin; Ohli, Jasmin; Bianchi, Edoardo; Kuteykin-Teplyakov, Konstantin; Grammel, Daniel; Ahlfeld, Julia; Schüller, Ulrich.

Affiliation

Pöschl J; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, 81377, Munich, Germany.

Acta Neuropathol ; 127(4): 605-7, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24531885

Subject(s)

Cerebellar Neoplasms/metabolism; Hedgehog Proteins/metabolism; Medulloblastoma/metabolism; Signal Transduction/physiology; Wnt Proteins/metabolism; beta Catenin/metabolism; Animals; Cells, Cultured; Cerebellar Neoplasms/genetics; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Hedgehog Proteins/genetics; Humans; Ki-67 Antigen/metabolism; Lithium Chloride/pharmacology; Medulloblastoma/genetics; Mice, Transgenic; Signal Transduction/drug effects; Signal Transduction/genetics; Wnt Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cerebellar Neoplasms / Wnt Proteins / Beta Catenin / Hedgehog Proteins / Medulloblastoma Limits: Animals / Humans Language: En Journal: Acta Neuropathol Year: 2014 Document type: Article Affiliation country: Germany

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