PET imaging with multimodal upconversion nanoparticles.
Dalton Trans
; 43(14): 5535-45, 2014 Apr 14.
Article
in En
| MEDLINE
| ID: mdl-24535647
ABSTRACT
A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the αvß3 integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) motif allows coordination to the radionuclide (68)Ga. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Contrast Media
/
Nanoparticles
Limits:
Animals
/
Humans
Language:
En
Journal:
Dalton Trans
Journal subject:
QUIMICA
Year:
2014
Document type:
Article
Affiliation country:
United kingdom