Rutin from Dendropanax morbifera Leveille protects human dopaminergic cells against rotenone induced cell injury through inhibiting JNK and p38 MAPK signaling.

Park, Se-Eun; Sapkota, Kumar; Choi, Jun-Hui; Kim, Myung-Kon; Kim, Young Hoi; Kim, Ki Man; Kim, Kyung Je; Oh, Ha-Na; Kim, Sung-Jun; Kim, Seung

Park, Se-Eun; Sapkota, Kumar; Choi, Jun-Hui; Kim, Myung-Kon; Kim, Young Hoi; Kim, Ki Man; Kim, Kyung Je; Oh, Ha-Na; Kim, Sung-Jun; Kim, Seung.

Affiliation

Park SE; Department of Alternative Medicine, Gwangju University, Gwangju, 503-703, Republic of Korea.

Neurochem Res ; 39(4): 707-18, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24549762

Subject(s)

Dopaminergic Neurons/enzymology; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Rotenone/toxicity; Rutin/pharmacology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Araliaceae; Cell Line, Tumor; Cell Survival/drug effects; Cell Survival/physiology; Dopaminergic Neurons/drug effects; Dose-Response Relationship, Drug; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Neuroprotective Agents/isolation & purification; Neuroprotective Agents/pharmacology; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Protein Kinase Inhibitors/isolation & purification; Rotenone/antagonists & inhibitors; Rutin/isolation & purification; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rotenone / Rutin / JNK Mitogen-Activated Protein Kinases / P38 Mitogen-Activated Protein Kinases / Protein Kinase Inhibitors / Dopaminergic Neurons Limits: Humans Language: En Journal: Neurochem Res Year: 2014 Document type: Article Country of publication: United States

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