Decreased response of interneurons in the medial prefrontal cortex to 5-HT1A receptor activation in the rat 6-hydroxydopamine Parkinson model.
Neurol Sci
; 35(8): 1181-7, 2014 Aug.
Article
in En
| MEDLINE
| ID: mdl-24563117
This study examined the response of interneurons in the medial prefrontal cortex (mPFC) to 5-HT1A receptor agonist 8-OH-DPAT and change in expression of 5-HT1A receptor on glutamate decarboxylase 67 (GAD67)-positive neurons in rats with 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta (SNc). Systemic administration of 5-HT1A receptor agonist 8-OH-DPAT dose-dependently inhibited the firing rate of the interneurons at all doses tested in sham-operated rats. In 6-OHDA-lesioned rats, 8-OH-DPAT, at the same doses, also inhibited the firing rate of the interneurons, whereas the inhibition was significant only at a high cumulative dose. Furthermore, injection of 8-OH-DPAT into the mPFC inhibited the interneurons in sham-operated rats, while having no effect on firing rate of the interneurons in 6-OHDA-lesioned rats. In contrast to sham-operated rats, SNc lesion reduced the expression of 5-HT1A receptor on GAD67-positive neurons in the prelimbic cortex, a sub-region of the mPFC. Our results indicate that degeneration of the nigrostriatal pathway leads to decreased response of mPFC interneurons to 5-HT1A receptor activation, which attributes to the down-regulation of 5-HT1A receptor expression in these interneurons.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
8-Hydroxy-2-(di-n-propylamino)tetralin
/
Prefrontal Cortex
/
Parkinsonian Disorders
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Receptor, Serotonin, 5-HT1A
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Serotonin 5-HT1 Receptor Antagonists
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Interneurons
Limits:
Animals
Language:
En
Journal:
Neurol Sci
Journal subject:
NEUROLOGIA
Year:
2014
Document type:
Article
Country of publication:
Italy