Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection.

Ward, Nicholas J; Ho, Karen W; Lambert, Wendi S; Weitlauf, Carl; Calkins, David J

Ward, Nicholas J; Ho, Karen W; Lambert, Wendi S; Weitlauf, Carl; Calkins, David J.

Affiliation

Ward NJ; Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232-0654.

J Neurosci ; 34(9): 3161-70, 2014 Feb 26.

Article in En | MEDLINE | ID: mdl-24573275

Subject(s)

Nerve Degeneration; Optic Nerve Diseases; Retinal Ganglion Cells/pathology; TRPV Cation Channels/deficiency; Visual Pathways/pathology; Animals; Axons/pathology; Cholera Toxin; Disease Models, Animal; Functional Laterality; Intraocular Pressure/genetics; Male; Membrane Potentials/genetics; Membrane Potentials/physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration/etiology; Nerve Degeneration/genetics; Nerve Degeneration/pathology; Ocular Hypertension/complications; Optic Nerve Diseases/etiology; Optic Nerve Diseases/genetics; Optic Nerve Diseases/pathology; Patch-Clamp Techniques; Rats; Retinal Ganglion Cells/metabolism; Superior Colliculi/metabolism; Superior Colliculi/pathology; TRPV Cation Channels/genetics

Key words

TRPV1; glaucoma; microbead glaucoma; optic nerve; retinal ganglion cell; superior colliculus

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Ganglion Cells / Visual Pathways / Optic Nerve Diseases / TRPV Cation Channels / Nerve Degeneration Type of study: Etiology_studies Limits: Animals Language: En Journal: J Neurosci Year: 2014 Document type: Article

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