Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury.

Moreno-Vinasco, Liliana; Quijada, Hector; Sammani, Saad; Siegler, Jessica; Letsiou, Eleftheria; Deaton, Ryan; Saadat, Laleh; Zaidi, Rafe S; Messana, Joe; Gann, Peter H; Machado, Roberto F; Ma, Wenli; Camp, Sara M; Wang, Ting; Garcia, Joe G N

Moreno-Vinasco, Liliana; Quijada, Hector; Sammani, Saad; Siegler, Jessica; Letsiou, Eleftheria; Deaton, Ryan; Saadat, Laleh; Zaidi, Rafe S; Messana, Joe; Gann, Peter H; Machado, Roberto F; Ma, Wenli; Camp, Sara M; Wang, Ting; Garcia, Joe G N.

Affiliation

Moreno-Vinasco L; 1 Institute for Personalized Respiratory Medicine and Department of Medicine, and.

Am J Respir Cell Mol Biol ; 51(2): 223-8, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24588101

Subject(s)

Acrylamides/pharmacology; Anti-Inflammatory Agents/pharmacology; Cytokines/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Lung/drug effects; Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors; Piperidines/pharmacology; Pneumonia/drug therapy; Respiratory Distress Syndrome/drug therapy; Ventilator-Induced Lung Injury/drug therapy; Animals; Apoptosis/drug effects; Bronchoalveolar Lavage Fluid/immunology; Caspase 3/metabolism; Cytokines/metabolism; Disease Models, Animal; Inflammation Mediators/metabolism; Lung/enzymology; Lung/immunology; Lung/pathology; Mice; Mice, Inbred C57BL; NAD/metabolism; Neutrophils/drug effects; Neutrophils/enzymology; Neutrophils/immunology; Nicotinamide Phosphoribosyltransferase/metabolism; Pneumonia/enzymology; Pneumonia/immunology; Pneumonia/pathology; Respiratory Distress Syndrome/enzymology; Respiratory Distress Syndrome/immunology; Respiratory Distress Syndrome/pathology; Ventilator-Induced Lung Injury/enzymology; Ventilator-Induced Lung Injury/immunology; Ventilator-Induced Lung Injury/pathology

Key words

FK-866; apoptosis; nicotinamide phosphoribosyltransferase; polymorphonuclear neutrophil; vascular endothelium

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pneumonia / Respiratory Distress Syndrome / Acrylamides / Cytokines / Enzyme Inhibitors / Nicotinamide Phosphoribosyltransferase / Ventilator-Induced Lung Injury / Lung / Anti-Inflammatory Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2014 Document type: Article Country of publication: United States

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