A cisplatin slow-release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol.

Oun, Rabbab; Plumb, Jane A; Wheate, Nial J

Oun, Rabbab; Plumb, Jane A; Wheate, Nial J.

Affiliation

Oun R; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom.
Plumb JA; Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom.
Wheate NJ; Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia. Electronic address: nial.wheate@sydney.edu.au.

J Inorg Biochem ; 134: 100-5, 2014 May.

Article in En | MEDLINE | ID: mdl-24595010

Subject(s)

Antineoplastic Agents/pharmacology; Bridged-Ring Compounds/chemistry; Cisplatin/pharmacology; Gelatin/chemistry; Hydrogels; Imidazoles/chemistry; Polyvinyl Alcohol/chemistry; Animals; Antineoplastic Agents/chemistry; Cell Line, Tumor; Cisplatin/chemistry; Delayed-Action Preparations; Drug Compounding; Drug Implants; Female; Humans; Injections, Intraperitoneal; Kinetics; Male; Mice; Mice, Nude; Tumor Burden/drug effects; Xenograft Model Antitumor Assays

Key words

Cisplatin; Cucurbituril; Drug delivery; Hydrogel; Polyvinyl alcohol; Slow release

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyvinyl Alcohol / Bridged-Ring Compounds / Cisplatin / Hydrogels / Gelatin / Imidazoles / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: J Inorg Biochem Year: 2014 Document type: Article Affiliation country: United kingdom Country of publication: United States

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