Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome.

Blondel, Sophie; Jaskowiak, Anne-Laure; Egesipe, Anne-Laure; Le Corf, Amelie; Navarro, Claire; Cordette, Véronique; Martinat, Cécile; Laabi, Yacine; Djabali, Karima; de Sandre-Giovannoli, Annachiara; Levy, Nicolas; Peschanski, Marc; Nissan, Xavier

Blondel, Sophie; Jaskowiak, Anne-Laure; Egesipe, Anne-Laure; Le Corf, Amelie; Navarro, Claire; Cordette, Véronique; Martinat, Cécile; Laabi, Yacine; Djabali, Karima; de Sandre-Giovannoli, Annachiara; Levy, Nicolas; Peschanski, Marc; Nissan, Xavier.

Affiliation

Blondel S; INSERM/Université Evry Val d'Essonne 861, and Centre d'Etude des Cellules Souches, Institut for Stem Cell Therapy and Exploration of Monogenic Diseases, Association Française Contre les Myopathies, Institute for Stem Cell Therapy and Exploration of Monogenic Diseases, Evry, France; INSERM-Aix-Marseille Université Unité Mixte de Recherche S 910 Génétique Médicale et Génomique Fonctionnelle, Faculté de Médecine Timone, Marseille, France; Department of Dermatology and IMETUM, Technische Universitat

Stem Cells Transl Med ; 3(4): 510-9, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24598781

Subject(s)

Anticholesteremic Agents/pharmacology; Bone Density Conservation Agents/pharmacology; Diphosphonates/pharmacology; Imidazoles/pharmacology; Induced Pluripotent Stem Cells/metabolism; Pravastatin/pharmacology; Progeria/metabolism; Animals; Cell Differentiation/drug effects; Cell Proliferation/drug effects; Child; Child, Preschool; Female; Humans; Induced Pluripotent Stem Cells/pathology; Infant; Lamin Type A; Male; Mice; Nuclear Proteins/metabolism; Osteoblasts/metabolism; Osteoblasts/pathology; Prenylation/drug effects; Progeria/drug therapy; Progeria/pathology; Protein Precursors/metabolism; Zoledronic Acid

Key words

Aging; Drug development; Mesenchymal stem cells; Pluripotent stem cells; Progeria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / Pravastatin / Diphosphonates / Bone Density Conservation Agents / Induced Pluripotent Stem Cells / Imidazoles / Anticholesteremic Agents Limits: Animals / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Stem Cells Transl Med Year: 2014 Document type: Article Country of publication: United kingdom

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