Cathelicidin antimicrobial peptide LL-37 augments interferon-ß expression and antiviral activity induced by double-stranded RNA in keratinocytes.

Takiguchi, T; Morizane, S; Yamamoto, T; Kajita, A; Ikeda, K; Iwatsuki, K

Takiguchi, T; Morizane, S; Yamamoto, T; Kajita, A; Ikeda, K; Iwatsuki, K.

Affiliation

Takiguchi T; Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Br J Dermatol ; 171(3): 492-8, 2014 Sep.

Article in En | MEDLINE | ID: mdl-24601852

Subject(s)

Cathelicidins/pharmacology; Herpes Simplex/drug therapy; Interferon-beta/biosynthesis; Keratinocytes/virology; RNA, Double-Stranded/physiology; Toll-Like Receptor 3/physiology; Antimicrobial Cationic Peptides; Antiviral Agents/pharmacokinetics; Antiviral Agents/pharmacology; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Herpes Simplex/immunology; Herpesvirus 1, Human/drug effects; Herpesvirus 1, Human/immunology; Humans; Immunity, Innate/drug effects; Interferon Inducers/pharmacokinetics; Interferon Inducers/pharmacology; Keratinocytes/immunology; Keratinocytes/metabolism; Poly I-C/pharmacokinetics; Poly I-C/pharmacology; Signal Transduction/drug effects; Toll-Like Receptor 3/drug effects; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Double-Stranded / Keratinocytes / Interferon-beta / Toll-Like Receptor 3 / Cathelicidins / Herpes Simplex Limits: Humans Language: En Journal: Br J Dermatol Year: 2014 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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