ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer.
Br J Cancer
; 110(8): 2030-9, 2014 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-24603303
ABSTRACT
BACKGROUND:
ASC amino-acid transporter 2 (ASCT2) is a major glutamine transporter that has an essential role in tumour growth and progression. Although ASCT2 is highly expressed in various cancer cells, the clinicopathological significance of its expression in non-small cell lung cancer (NSCLC) remains unclear.METHODS:
One hundred and four patients with surgically resected NSCLC were evaluated as one institutional cohort. Tumour sections were stained by immunohistochemistry (IHC) for ASCT2, Ki-67, phospho-mTOR (mammalian target of rapamycin), and CD34 to assess the microvessel density. Two hundred and four patients with NSCLC were also validated by IHC from an independent cohort.RESULTS:
ASC amino-acid transporter 2 was expressed in 66% of patients, and was closely correlated with disease stage, lymphatic permeation, vascular invasion, CD98, cell proliferation, angiogenesis, and mTOR phosphorylation, particularly in patients with adenocarcinoma (AC). Moreover, two independent cohorts confirmed that ASCT2 was an independent marker for poor outcome in AC patients.CONCLUSIONS:
ASC amino-acid transporter 2 expression has a crucial role in the metastasis of pulmonary AC, and is a potential molecular marker for predicting poor prognosis after surgery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prognosis
/
Biomarkers, Tumor
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Carcinoma, Non-Small-Cell Lung
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Amino Acid Transport System ASC
Type of study:
Prognostic_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Br J Cancer
Year:
2014
Document type:
Article
Affiliation country:
Japan