Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.

Ronzoni, Luisa; Sonzogni, Laura; Fossati, Gianluca; Modena, Daniela; Trombetta, Elena; Porretti, Laura; Cappellini, Maria Domenica

Ronzoni, Luisa; Sonzogni, Laura; Fossati, Gianluca; Modena, Daniela; Trombetta, Elena; Porretti, Laura; Cappellini, Maria Domenica.

Affiliation

Ronzoni L; Department of Clinical Sciences and Community, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy; UO Genetica Medica, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Br J Haematol ; 165(5): 714-21, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24606390

Subject(s)

Carbamates/pharmacology; Gene Expression Regulation/drug effects; Histone Deacetylase Inhibitors/pharmacology; gamma-Globins/biosynthesis; Adult; Anemia, Sickle Cell/blood; Antigens, CD34/blood; Butyric Acid/pharmacology; Carbamates/administration & dosage; Cell Differentiation/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical/methods; Erythroid Precursor Cells/drug effects; Erythroid Precursor Cells/metabolism; Erythropoiesis/drug effects; Hemoglobins/biosynthesis; Histone Deacetylase Inhibitors/administration & dosage; Humans; Hydroxyurea/pharmacology; gamma-Globins/genetics

Key words

fetal haemoglobin induction; globin gene transcription; histone deacetylase inhibitor; sickle cell disease; ß-thalassaemia

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carbamates / Gene Expression Regulation / Gamma-Globins / Histone Deacetylase Inhibitors Limits: Adult / Humans Language: En Journal: Br J Haematol Year: 2014 Document type: Article Affiliation country: Italy

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