A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.
J Biol Chem
; 289(16): 10950-10957, 2014 Apr 18.
Article
in En
| MEDLINE
| ID: mdl-24610814
ABSTRACT
The recent discovery of numerous human short open reading frame (sORF)-encoded polypeptides (SEPs) has raised important questions about the functional roles of these molecules in cells. Here, we show that a 69-amino acid SEP, MRI-2, physically interacts with the Ku heterodimer to stimulate DNA double-strand break ligation via nonhomologous end joining. The characterization of MRI-2 suggests that this SEP may participate in DNA repair and underscores the potential of SEPs to serve important biological functions in mammalian cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Open Reading Frames
/
DNA Helicases
/
DNA Breaks, Double-Stranded
/
DNA End-Joining Repair
Limits:
Humans
Language:
En
Journal:
J Biol Chem
Year:
2014
Document type:
Article