Nitric oxide pretreatment enhances atheroma component highlighting in vivo with intercellular adhesion molecule-1-targeted echogenic liposomes.
Ultrasound Med Biol
; 40(6): 1167-76, 2014 Jun.
Article
in En
| MEDLINE
| ID: mdl-24613216
ABSTRACT
We present an ultrasound technique for the detection of inflammatory changes in developing atheromas. We used contrast-enhanced ultrasound imaging with (i) microbubbles targeted to intercellular adhesion molecule-1 (ICAM-1), a molecule of adhesion involved in inflammatory processes in lesions of atheromas in New Zealand White rabbits, and (ii) pretreatment with nitric oxide-loaded microbubbles and ultrasound activation at the site of the endothelium to enhance the permeability of the arterial wall and the penetration of ICAM-1-targeted microbubbles. This procedure increases acoustic enhancement 1.2-fold. Pretreatment with nitric oxide-loaded echogenic liposomes and ultrasound activation can potentially facilitate the subsequent penetration of targeted echogenic liposomes into the arterial wall, thus allowing improved detection of inflammatory changes in developing atheromas.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelium, Vascular
/
Intercellular Adhesion Molecule-1
/
Contrast Media
/
Plaque, Atherosclerotic
/
Liposomes
/
Nitric Oxide
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Ultrasound Med Biol
Year:
2014
Document type:
Article