ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma.

Miller, Marina; Rosenthal, Peter; Beppu, Andrew; Mueller, James L; Hoffman, Hal M; Tam, Arvin B; Doherty, Taylor A; McGeough, Matthew D; Pena, Carla A; Suzukawa, Maho; Niwa, Maho; Broide, David H

Miller, Marina; Rosenthal, Peter; Beppu, Andrew; Mueller, James L; Hoffman, Hal M; Tam, Arvin B; Doherty, Taylor A; McGeough, Matthew D; Pena, Carla A; Suzukawa, Maho; Niwa, Maho; Broide, David H.

Affiliation

Miller M; Department of Medicine, University of California, San Diego, La Jolla, CA 92093;

J Immunol ; 192(8): 3475-87, 2014 Apr 15.

Article in En | MEDLINE | ID: mdl-24623133

Subject(s)

Airway Remodeling/genetics; Airway Remodeling/immunology; Asthma/genetics; Asthma/immunology; Membrane Proteins/genetics; Activating Transcription Factor 6/metabolism; Allergens/immunology; Animals; Antibody Specificity/immunology; Asthma/pathology; Bronchial Hyperreactivity/chemically induced; Chemokines, CC/metabolism; Chemokines, CXC/metabolism; Cytokines/metabolism; Disease Models, Animal; Eosinophils/immunology; Eosinophils/metabolism; Gene Expression; Gene Order; Gene Targeting; Humans; Immunoglobulin E/blood; Immunoglobulin E/immunology; Inflammation/immunology; Inflammation/metabolism; Inflammation/pathology; Lung/immunology; Lung/metabolism; Lung/pathology; Methacholine Chloride/administration & dosage; Mice; Mice, Transgenic; Ovalbumin/immunology; Th2 Cells/immunology; Th2 Cells/metabolism; Transgenes; Unfolded Protein Response; eIF-2 Kinase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Airway Remodeling / Membrane Proteins Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2014 Document type: Article Country of publication: United States

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