Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5Î³2 signaling pathway.

Zhang, Jing-Tao; Sun, Wei; Zhang, Wen-Zhong; Ge, Chun-Yan; Liu, Zhong-Yan; Zhao, Ze-Ming; Lu, Xing-Sui; Fan, Yue-Zu

Zhang, Jing-Tao; Sun, Wei; Zhang, Wen-Zhong; Ge, Chun-Yan; Liu, Zhong-Yan; Zhao, Ze-Ming; Lu, Xing-Sui; Fan, Yue-Zu.

Affiliation

Fan YZ; Department of Surgery, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai 200065, P,R, China. fanyuezu@hotmail.com.

BMC Cancer ; 14: 193, 2014 Mar 15.

Article in En | MEDLINE | ID: mdl-24628713

Subject(s)

Antineoplastic Agents/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Gallbladder Neoplasms/pathology; Neovascularization, Pathologic/pathology; Signal Transduction/drug effects; Animals; Cell Line, Tumor; Cell Movement/drug effects; Cell Proliferation/drug effects; Female; Gallbladder Neoplasms/metabolism; Gene Expression Regulation, Neoplastic/drug effects; Humans; Male; Matrix Metalloproteinases/genetics; Matrix Metalloproteinases/metabolism; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Neovascularization, Pathologic/metabolism; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Bridged Bicyclo Compounds, Heterocyclic / Gallbladder Neoplasms / Neovascularization, Pathologic / Antineoplastic Agents Limits: Animals / Female / Humans / Male Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2014 Document type: Article

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