ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells.

Stellrecht, Christine M; Vangapandu, Hima V; Le, Xiao-Feng; Mao, Weiqun; Shentu, Shujun

Stellrecht, Christine M; Vangapandu, Hima V; Le, Xiao-Feng; Mao, Weiqun; Shentu, Shujun.

Affiliation

Stellrecht CM; Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Unit 1950, P,O, Box 301429, Houston, TX 77230-1429, USA. cmstellre@mdanderson.org.

J Hematol Oncol ; 7: 23, 2014 Mar 14.

Article in En | MEDLINE | ID: mdl-24628795

Subject(s)

2-Chloroadenosine/analogs & derivatives; AMP-Activated Protein Kinases/metabolism; Apoptosis/drug effects; Breast Neoplasms/drug therapy; 2-Chloroadenosine/pharmacology; Animals; Autophagy/drug effects; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Disease Models, Animal; Female; Humans; MCF-7 Cells; Mice; Phosphorylation/drug effects; Random Allocation; Signal Transduction/drug effects; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / 2-Chloroadenosine / Apoptosis / AMP-Activated Protein Kinases Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2014 Document type: Article Affiliation country: United States Country of publication: United kingdom

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