IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.

Rokavec, Matjaz; Öner, Meryem Gülfem; Li, Huihui; Jackstadt, Rene; Jiang, Longchang; Lodygin, Dmitri; Kaller, Markus; Horst, David; Ziegler, Paul K; Schwitalla, Sarah; Slotta-Huspenina, Julia; Bader, Franz G; Greten, Florian R; Hermeking, Heiko

Rokavec, Matjaz; Öner, Meryem Gülfem; Li, Huihui; Jackstadt, Rene; Jiang, Longchang; Lodygin, Dmitri; Kaller, Markus; Horst, David; Ziegler, Paul K; Schwitalla, Sarah; Slotta-Huspenina, Julia; Bader, Franz G; Greten, Florian R; Hermeking, Heiko.

J Clin Invest ; 124(4): 1853-67, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24642471

Subject(s)

Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; MicroRNAs/genetics; MicroRNAs/metabolism; Receptors, Interleukin-6/genetics; Receptors, Interleukin-6/metabolism; STAT3 Transcription Factor/metabolism; Animals; Cell Line, Tumor; Colorectal Neoplasms/pathology; Disease Models, Animal; Epithelial-Mesenchymal Transition; Feedback, Physiological; Female; Humans; Male; Mice; Mice, Knockout; Neoplasm Invasiveness; Neoplasm Metastasis; Snail Family Transcription Factors; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Receptors, Interleukin-6 / MicroRNAs / STAT3 Transcription Factor Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Clin Invest Year: 2014 Document type: Article Country of publication: United States

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